acute myeloid leukemia (aml): the role of maintenance chemo¬therapy

acute myeloid leukemia (aml): the role of intensive induction chemotherapy

intensive induction therapy-in acute myeloid leukemia (aml), as in some other systemic malignancies- is a strategy fundamentally different from post-remission strategies. approaches like consolidation treatment, prolonged mainte nance, and autologous or allogeneic transplantation in the first remission are directed against minimal residual disease with a malignant cell population having survive...

The role of microRNA in acute/chronic, myeloid/lymphocytic leukemia

MicroRNAs are small, non-coding sequences that regulate gene expression by inducing degradation or translational inhibition of target mRNAs. These molecules control many intracellular physiological and pathological processes.Abnormal expression of these moleculs has been described in different cancers including hematopoietic cancers. According to the type of cancer and the stage, miRNA’s expres...

Chromosomal rearrangements in acute myeloid leukemia (AML)

E Belloni, M Trubia, P Gasparini, C Micucci, C Tapinassi, S Confalonieri, P Nuciforo, B Martino, F Lo-Coco, PP Di Fiore and PG Pelicci Istituto Europeo di Oncologia, Milan, Italy Campus IFOM-IEO, Milan, Italy Divisione di Ematologia, Azienda Ospedaliera Bianchi-Malacrino-Morelli, Reggio Calabria, Italy Università di Roma Tor Vergata, Department of Biopatologia e Diagnostica per Immagini, Rome, ...

Effective Dendritic Cell-based Immunotherapeutic Vaccines for Acute Myeloid Leukemia (AML)

Acute myeloid leukemia (AML) is a type of poor prognosis hematological malignancies characterized by heterogeneous clonal expansion of myeloid progenitors. Leukemic stem cells are thought to form the majority of a cell population in minimal residual diseases (MRDs) which are resistant to current chemotherapeutic regimens and mediate disease relapse. Current therapeutic vaccine strategies have d...

Occurrence of Secondary Acute Myeloid Leukemia in a Patient with Breast Cancer after Chemotherapy

Induction Chemotherapy for Acute Myeloid Leukemia – Experiences from the AML-CG Studies

O ver the last three decades the overall prognosis of patients suffering from AML has steadily improved. Nowadays, complete remissions are achieved in 60 – 70% of all patients with long-term disease free survival and potential cure in 25 – 40% of cases. A more detailed analysis indicates that this progress has mainly been achieved in patients <60 years of age while in older patients little impr...